Issue no. 1

International team sheds new light on biology underlying schizophrenia Genes, pathways identified could inform new approaches to treatment

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Genetic researchers from 34 countries have joined forces to take a closer look at the biological causes of schizophrenia. iPSYCH scientists from Aarhus University and Mental Health Centre Sct. Hans and Bispebjerg are among those to pinpoint 80 new genes linked to the development of schizophrenia. Their research may pave the way for possible new treatments. Read more

Late miscarriages and stillbirths cause mothers to become psychologically vulnerable

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Trine Munk-Olsen, Senior Researcher, National Centre for Register-based Research, Aarhus University

Losing an unborn child is a traumatic experience, and many women who go through this have to be admitted to psychiatric treatment. Such are the results of a new study by iPSYCH scientists from Aarhus University. Read more.

Risk of schizophrenia increases after all child and adolescent psychiatric disorders

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Cecilie Maibing, MD Student, Mental Health Centre Copenhagen, Bispebjerg

All childhood psychiatric disorders were found to increase the risk of schizophrenia later in life. Such are the results of a new study by iPSYCH scientists from Mental Health Centre Copenhagen and Aarhus University. Read more.

CNVs conferring risk of autism or schizophrenia affect cognition in controls

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Johan Thygesen, PhD student, Institute of Biological Psychiatry, Mental Health Centre Sct. Hans

Certain rare copy-number variants in the genome have been linked to schizophrenia and autism, but despite of this, their carriers do not always suffer from the diseases. In this paper recently published in Nature, the authors find an explanation why some CNV carriers suffer from diseases, while others are disease-free. Such are the results from a study by iPSYCH scientists from Mental Health Centre Sct. Hans. Read more.

Learn about your attitudes towards pertinent and incidental findings in whole genome sequencing research!

Genetic analyses of DNA now reveal more about a research subject than ever before - including past, present and future health.

When people today agree to participate in a whole genome sequencing study, their entire genomes are examined in order to identify all genetic variants associated with the disorder of interest. These findings are the pertinent findings. But in addition, the researchers may uncover increased risks of other disorders, e.g. breast cancer or Alzheimer’s – the incidental findings. It is not standard practice to share all this information with the research subject - but should it be?

Perhaps you were one of the researchers in iPSYCH who participated in our small survey conducted at the iPSYCH Annual Meeting 2014?

We wanted to evaluate attitudes towards pertinent and incidental findings from whole genome sequencing studies among members of iPSYCH. You are all individuals actively involved in genetic research on human subjects. The objective of our survey was to explore your attitudes towards: i) sharing pertinent findings from whole genome studies, and (ii) sharing incidental findings from whole genome studies. See results