Aims: Institute for Biological Psychiatry aims (a) to discover rare and common genetic variants that confer risk of developing severe psychiatric disorders, and (b) to describe the patterns of biological and functional impact of such disease variants.
Impact: The institute has made a number major scientific discoveries, primarily identifying rare, high-risk CNVs and common, low-risk SNPs, and implicating microRNA mediated deregulation in the pathogenesis of schizophrenia. Another recent and significant contribution by the institute was the mapping of the genetic population sub-structure among European Caucasians and the development of algorithms for genetic stratification. The institute has recently developed genetic animal models of mental disorders inserting human disease CNV mutations into mouse strain using transgenic techniques, and shown that the phenotypic impact of such CNV mutations can be translated across species.
Interests: The institute is home for the Danish Psychiatric Biobank and focuses on three scientific topics. (a) Molecular and Population Genetics, aiming at gene discovery and association with psychiatric disorders, including risk assessment, environmental impact, inheritance patterns in large population, and sub-structuring of populations. (b) Translational Genomics, pursuing a “from-cause-to-outcome” strategy to track the path of pathogenic mutations, through its molecular and cellular correlates to the pathophysiological outcomes and functional deficits. (c)Systems Pharmacology, which combines genomics and metabolomic sciences with careful clinical assessments to identify causes and biomarkers of pharmacotherapy in important mental and somatic disorders.
Expertise: The field of expertise covers molecular genetics, bioinformatics, systems biology, clinical phenotyping, translational genetics, imaging genetics, neuro-cognition, psychopathology, EEG, MR, pharmaco genetics, population genetics, metabolomics, gene-environment interactions. The institute comprises an interdisciplinary team of geneticists, biostatisticians, molecular biologists, physicians, bioinformatics, psychologists, physicists and biologists.
Publications: The institute holds a number of large, research grants and collaborates with many different national and international research institutions and private companies. Results from the research are published in highly renowned peer-review journals including Nature, Nature Genetics, Nature Biotechnology, Current Biology, Biological Psychiatry, Molecular Psychiatry, Proceedings of the National Academy of Science, American Journal of Human Genetics, American Journal of Psychiatry, Human Molecular Genetics, Genetic Epidemiology, and JAMA Psychiatry.
Read more about Professor Thomas Werge.